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Unlike the depression drugs available for decades, neither of the two new drugs is a pill. One is a nasal spray; the latest is an injection made by Sage.
Sage's new antidepressant may be called a "blockbuster" for good reason: it appears to be the first to differ significantly from 35 years worth of treatments.
A fresh crop of promising drugs is poised to change the way depression is treated for the first time in decades. Here are the ones to watch in 2019.
Researchers are on the hunt for better drugs to treat depression, a leading cause of disability worldwide. Promising options include ketamine and psilocybin.